Azumanga Daioh is about high school life through the eyes of six girls with unusual personalities: Chiyo (the 10-year-old genius), Osaka (the resident airhead), Sakaki (the shy one prone to cat bites), Tomo (the loose cannon), Yomi (the short-tempered one) and Kagura (the resident jock).
The story has no real Plot to speak of, simply interactions between the characters as the go through school. Entertaining slap-stick, but nothing of particular note.